Odeo CEO (and Nebraska native), Evan Williams has some great advice for web-based startups. And he ought to know, having co-founded Blogger, which is now part of Google.
#1: Be Narrow
#2: Be Different
#3: Be Casual
#4: Be Picky
#5: Be User-Centric
#6: Be Self-Centered
#7: Be Greedy
#8: Be Tiny
#9: Be Agile
#10: Be Balanced
#11 (bonus!): Be Wary
#12 Be Thorough (by reading Evan’s post for the full run down on each point).